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Approach to the Hypernatremic Patient

Of Water, Electrolytes, and Acid-BaseApproach to the Hypernatremic PatientFIGURE 1-29 Pathogenesis of hypernatremia. The renalconcentrating mechanism is the first line ofdefense against water depletion and hyper-osmolality. When renal concentration isimpaired, thirst becomes a very effectivemechanism for preventing further increasesin serum osmolality. The components of thenormal urine concentrating mechanism areshown in Figure 1-2. Hypernatremia resultsfrom disturbances in the renal concentratingmechanism. This occurs in interstitial renaldisease, with administration of loop andosmotic diuretics, and with protein malnu-trition, in which less urea is available togenerate the medullary interstitial tonicity.

1.16 Disorders of Water, Electrolytes, and Acid-Base Approach to the Hypernatremic Patient FIGURE 1-29 Pathogenesis of hypernatremia. The renal concentrating mechanism is the first line of defense against water depletion and hyper-

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