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化療止吐藥 Aprepitant ( Emend ... - …

1 ( tsgh Pharmacy Newsletter) 76 75 12 96 11 Aprepitant ( Emend ) (emesis) ( Chemotherapy induced nausea and vomiting, CINV ) ( acute CINV ) serotonin 24 ( delayed CINV ) substance P 24 ( anticipatory CINV ) CINV ( 90% ) ( 30% 90% ) ( 10% 30% ) ( < 10% )( ) Aprepitant ( Emend ) 2 70 - 80 5-HT3 receptor antagonist ( Granisetron Ondansetron ) Dexamethasone cisplatin 5- HT3 receptor antagonist substance P neurokinin ( NK1 ) receptor Aprepitant ( Emend ) 2005 NK1 receptor antagonist Aprepitant neurokinin 1 ( NK1 ) receptors

三總藥訊96.11 1 (TSGH Pharmacy Newsletter) (76)國報字第 一號 三軍總醫院 臨床藥學部 藥物諮詢室 洪乃勻藥師主編

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