Transcription of ARTICLES - AC Forum
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ARTICLES - AC Forum
Standardized prophylaxis or treatmentdoses of low-molecular-weight hep-arins (LMWHs) can be used in most pa-tients without dose adjustment. Howev-er, there are concerns about whetherdose adjustments are needed to optimizeanticoagulation in certain patient popula-tions. Specifically, these concerns relateto the potential for increased bleedingdue to LMWH accumulation in patientswith impaired renal function and aboutwhether and when dose adjustments areneeded for obese patients. However, un-warranted down-adjustment of dosingcould compromise clinical article reviews currently avail-able information on the use of LMWHsin patients with impaired renal function orobesity and formulates practical recom-mendations for dosing and monitoring inthese specific subpopulations (Table 1).
May 19, 2009 · www.theannals.com The Annals of Pharmacotherapy 2009 June, Volume 43 1065 Table 1. Summary of LMWH Dosage Recommendations Patients Recommendations Dalteparin PI Enoxaparin PI Tinzaparin PI
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