PDF4PRO ⚡AMP

Modern search engine that looking for books and documents around the web

Example: quiz answers

ASSAY DEVELOPMENT IN DRUG DISCOVERY

ASSAY DEVELOPMENT IN DRUG DISCOVERYI ndira Padmalayam, DISCOVERY Division, Southern Research Institute, Birmingham, Alabama 35205 The Drug DISCOVERY Process:The ASSAY DEVELOPMENT StageAssay developmentPrimary assays Secondary assaysTarget IdentificationTarget ValidationAssayDevelopmentHTSLead IdentificationLead OptimizationDevelopment Hit validationChemistryStructure-Activity Relationship (SAR)bioavailability (PK, ADME), toxicityIn vivo efficacyPre-clinicalGLP-ToxClinicalTarge t IdentificationTarget ValidationAssayDevelopmentLead Optimization DevelopmentHTSNon-HTSA ssay DEVELOPMENT : A critical part of the hit DISCOVERY process HITS A hit is a compound which has the desired activity in acompound screen and whoseactivity is confirmed upon retestingAdapted frrom: Hughes, (2011), British Journal of Pharmacology, 162 1239-1249 Secondary assaysPrimary assaysAssay DevelopmentPre-Roadblocks to faster ASSAY DEVELOPMENT Why is this a bottleneck?

-Homogenous assay format-Reduced assay time and cost (HTS friendly) ... Assay development: From the bench to HTS (HTS 101) Assay development: From the bench to HTS. ASSAY QC PARAMETERS • “Z” factor: Key measure of readiness of an assay for HTS Z > 0.5

Fullscreen Download
Loading..

Tags:

  Assay, Format, Assay format

Information

Domain:

Source:

Link to this page:

Please notify us if you found a problem with this document:

Spam in document Broken preview Other abuse

Transcription of ASSAY DEVELOPMENT IN DRUG DISCOVERY

Documents from same domain

ENLISTMENT/REENLISTMENT DOCUMENT ARMED …

www.uab.edu

D. CERTIFICATION AND ACCEPTANCE NAME OF ENLISTEE/REENLISTEE (Last, First, Middle) SOCIAL SECURITY NO. OF ENLISTEE/REENLISTEE DD FORM 4/2, OCT 2007 13a. My acceptance for enlistment is based on the information I have given in my application for enlistment.

  Form, Applications, Document, Dreams, Reenlistment, Enlistment, Enlistment reenlistment document armed, For enlistment, Application for enlistment

Admission Application Checklist & Instructions

www.uab.edu

Recommendations: Three (3) letters of professional reference and recommendation forms attesting to the applicant’s potential for graduate study.

  Applications, Instructions, Admission, Admission application

Personal Statement Makeover - UAB

www.uab.edu

Personal Statement Makeover: Workshop for NIH My Biosketch July 27 th 2015 Jennifer L. Greer, PhD, UAB Graduate School, Professional Development Program (PDP)

  Testament, Personal, Personal statement makeover, Makeover

Review R eview of the methods used in the …

www.uab.edu

C.-C.Wang et al. / J.Chromatogr.B 777 (2002) 3–28 5 Table 1 Comparison of analytical methods for analysis of phytoestrogens Technique Sensitivity Specificity Pros Cons

  Analysis, 2200, 3 28

ARMY RESERVE RECORD OF INDIVIDUAL …

www.uab.edu

ARMY RESERVE RECORD OF INDIVIDUAL PERFORMANCE OF RESERVE DUTY TRAINING For use of this form see AR 140-185; the proponent agency is OCAR 13. FOR CUSTODIAN OF INDIVIDUAL RESERVIST’S RECORDS

  Reserve, Performance, Individuals, Record, Agency, Duty, Record of individual, Record of individual performance of reserve duty

Basics of mass spectrometry - UAB

www.uab.edu

Basics of mass spectrometry Stephen Barnes, PhD Department of Pharmacology & Toxicology and Mass Spectrometry Shared Facility, UAB. UAB Botanicals Workshop September 11, 2006 Synopsis • Transferring analytes from the liquid phase to the gas phase following LC analysis without damaging them

  Basics, Mass, Spectrometry, Mass spectrometry

Nucleic acid mass spectrometry - UAB

www.uab.edu

2/2/2011 5 Fundamentals of nucleic acids analysis by ESI-mass spectrometry •Analysis as bases, nucleosides –No different from other small molecules –Bases are sufficiently hydrophobic to be analyzed by reverse-phase LC-MS •The addition of ribose or deoxyribose not a problem •Detected in the positive ion mode •Nucleotides are more …

  Mass, Spectrometry, Mass spectrometry

2017 2018 Student Handbook - uab.edu

www.uab.edu

University of Alabama at Birmingham 2017 – 2018 Student Handbook Department of Human Studies Counselor Education Program Sean Hall, Ph.D., Assistant Professor, Clinic Director Larry Tyson, Ph.D., Associate Professor Shannon McCarthy, Ph.D., Assistant Professor Dayna Watson, Ph.D.

  2017, Handbook, Students, 2018, Student handbook 2017 2018

Shipping Dangerous Goods at UAB

www.uab.edu

Shipping Dangerous Goods at UAB Shipping Dangerous Goods at UAB Page 6 Last Updated: 08/18/2017 Operator (or Carrier) Responsibilities The Operator (or carrier) is the person(s) responsible for transporting the material from the origin to the destination.

  Good, Dangerous, Shipping, Shipping dangerous goods at uab, Shipping dangerous goods at uab shipping dangerous goods at uab

UNIVERSITY OF ALABAMA AT BIRMINGHAM - uab.edu

www.uab.edu

University of Alabama at Birmingham Common Data Set: 2016-2017 05/19/17 5 entered your institution during the summer term preceding fall 2009. entered your institution during the summer term preceding fall 2010. B4. Initial 2009 cohort of first-time, full-time bachelor’s (or equivalent) degree-seeking undergraduate ...

  University, Alabama, Birmingham, University of alabama at birmingham