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ASTCT Consensus Grading for CRS and ICANS

ASTCT Consensus Grading for CRS and ICANSS attva S. Neelapu, and Deputy Chair ad interimDepartment of Lymphoma and MyelomaThe University of Texas MD Anderson Cancer CenterHouston, TXCAR T and Related Immune Effector Cell Therapies ASGCT WorkshopWashington DC, April 28, 2019 Disclosures Research support from Kite/Gilead, Merck, BMS, Cellectis, Poseida, Karus, Acerta, and Unum Therapeutics Advisory Board Member / Consultant for Kite/Gilead, Merck, Celgene, Novartis, Unum Therapeutics, Pfizer, Precision Biosciences, CellMedica, Allogene, and in multicenter CD19 CAR T trials in adult NHLS tudy/SponsorProductNCRS All GradesCRS Grade 3NT All GradesNT Grade 3 RefZUMA1 KiteCD19/CD3z/CD2810892%11%67%32%Neelapu et al, NEJM 2017 JULIETN ovartisCD19/CD3z/4-1BB11158%22%21%12%Sch uster et al, NEJM 2019 TRANSCEND JunoCD19/CD3z/4-1BB7337%1%25%15%Abramson et al, ASCO 2018 Lee criteria used for CRS Grading on ZUMA1 and TRANSCEND U Penn criteria used for CR

For patients age 1-2 years, the following serve as guidelines to the corresponding questions: 1. Holds gaze. Prefers primary parent. Looks at speaker. 2. Reaches and manipulates objects, tries to change position, if mobile may try to get up 3. Prefers primary parent, upset when separated from preferred caregivers. Comforted by familiar

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