Transcription of Atmospheric Pressure Ionization (API)
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Atmospheric Pressure Ionization (API)
1 Atmospheric Pressure Ionization (API) conventional Ionization methods employ sources that are at high vacuum (EI, CI, FI/FD, FAB/LSIMS, MALDI) and/or temperature (EI, CI, FI/FD) the introduction of API sources employing a number of different types of Ionization has allowed very robust instruments to be developed for LC/MS These new Ionization techniques have greatly extended the range of analytes that can be studied by MS to compounds that are high molecular weight, thermally labile and polar. While the sources are designed to operate at Atmospheric Pressure we must still maintain a high vacuum in the rest of the instrument if we want to perform mass spectrometry!
1 Atmospheric Pressure Ionization (API) • conventional ionization methods employ sources that are at high vacuum (EI, CI, FI/FD, FAB/LSIMS, MALDI) and/or …
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