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Baran, Newhouse, Seiple Essentials of Heterocyclic ...
Heterocyclic ChemistryBaran, Newhouse, SeipleEssentials of Heterocyclic chemistry -IVIsoindoles:NPhthalOPhN2H4 EtOHNHPhPhOPhONMePhPhMeNH2 NaBH4 PhOPhOMeMeSPhPhP4S10 SMeMeOOSMeMeMeMeOHOHMeMeSPhPhCHOOHCSOOPh PhOMeMeOi. ii. O3 RROHOOClOCO2 HHOOCHOCO2 HOAc2O, NaOAc,AcOH, ONMeOMeMeBF3, AcOHOHIOHIOOMeMeOPd(OAc)2, basethen BF3 OCO2 MeTIPSRPd(OAc)2, baseORSEtOOEtSPPAFCHOSHSCO2 MeNaHBenzo[c]thiophenes:Benzothiophenes: Benzofurans:HO2 CNHRRRNRRRODICEtO2 CNHRRRNHRRRLHMDSOStButBuMgClNOPhPhNArArn BuLiCO2tBuRNRTMSLDABeta-lactams:RO2 CRBrNArRZnHFNaOH TIPSMeMeCO2 MeOxetanes:ORR1R2R3 ORR1R2R3h OHR1 RMsOnBuNOAcSSObase Paterno-B chi ReactionOR1 RThiazoles and Isothiazoles:MeXOX = N2 or Cl,HMeSH2N+NSMeMeHantzsch Thiazole SynthesisXOSMeSH2N+NSi. aq. ROHii. Li/NH3R1SR2 OONH4 OAcNSMeMeRSHNSTosMICRHOi. Na2S2O3ii. NH3 NSRO2 CMeNH2i. TsNCSii. I2, pyNNHTsRO2 CMeImidazoles:OOBrH2 NOH+NH3, NHNR1 OBrNH2H2 NNR2 NHN+R1 NHR2 RHNHTosMICNHNRiPrOBrCHONH2 ArNR+K2CO3 ArHNNOHCCNEtOOEti.
Baran, Newhouse, Seiple Essentials of Heterocyclic Chemistry-IV Heterocyclic Chemistry Top 15 Brand-Name Pharmaceuticals with Heterocycles: O NH HO Me O MeO O H NMe ON CO2H H CO2H Me Me S H HN H2N OH O N O HO MeN N N Cl Ph N HO N Cl Cl N OH O Me O Ph
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