Transcription of Basic Antibody Structure
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Basic Antibody Structure
1 Chapter 4. Immunoglobulin Structureand Function1. Functional Regions2. Types of chains3. Constant &Variable regions4. Glycoprotein- Each heavy and light chainis made up of a number ofdomains(= Ig folding or Igdomains).- Light chains consist of 2 domains (C and V).- Heavy chains have 4-5 domains(depending on the class of Antibody )- Each domain is about 110amino acidsin length andcontains an intrachaindisulfide bond between two cysteines about 60 amino acids chain= 446 aaLight chain= 214aa1122**-150,000 molecular weight-Constant (C) and Variable (V) regionsWhat is the difference?1234 Basic Antibody Structure Multiple myeloma = cancerous plasma cells Monomer = 150,000212 Fab + Fc2 H + 2 L(Fab)2100,000 MW2 (45,000)1 (50,000) 2 (50,0000)2 (25,000) 1 Papain23 PepsinMercaptoethanolRECAP:- The Fc region plays NO role in antigen antigen molecules into 2 Fab fragments and an Fc fragment.
Basic Antibody Structure • Multiple myeloma = cancerous plasma cells • Monomer = 150,000. 2 1 2 Fab + Fc 2 H + 2 L (Fab) 2 100,000 MW 2 (45,000) 1 (50,000) 2 (50,0000) 2 (25,000) 1 Papain 2 3 Pepsin Mercaptoethanol RECAP: - The Fc region plays NO role in antigen binding.
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