Transcription of Basic Pharmacokinetics Sample Chapter - Pharmaceutical Press
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Basic Pharmacokinetics Sample Chapter - Pharmaceutical Press
Copyright Pharmaceutical Press 6. Extravascular routes of drug administration Introduction 106 Some important comments on the 116. absorption rate constant Drug remaining to be absorbed, or drug 106. remaining at the site of administration The apparent volume of distribution (V) 116. Determination of elimination half life 109 Time of maximum drug concentration, 117. (t1/2 ) and elimination rate constant (K or peak time (tmax ). Kel ). Maximum (peak) plasma concentration 118. Absorption rate constant (Ka ) 110 (Cp )max Wagner Nelson method 111 Some general comments 120. (one-compartment model) and Loo Riegelman method Example for extravascular route of drug 121. (two-compartment model) administration Lag time (t0 ) 115 Flip-flop kinetics 126. Objectives Upon completion of this Chapter , you will have the ability to: calculate plasma drug concentration at any given time after the administration of an extravascular dose of a drug, based on known or estimated pharmacokinetic parameters interpret the plasma drug concentration versus time curve of a drug administered extravascularly as the sum of an absorption curve and an elimination curve employ extrapolation techniques to characterize the absor
form and dissolution becomes very critical for the absorption of a drug. The passage of drug molecules from the gastrointestinal tract to the general circula-tion and factors affecting this are shown in Figs 6.1 and 6.2. Any factor influencing dissolution of the drug is likely to affect the absorption of a drug. These
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