Transcription of Bioinformatics Explained Blast - UNAM
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Bioinformatics Explained Blast - UNAM
Bioinformatics Bioinformatics ExplainedExplainedBioinformatics Explained : BLASTM arch 8, 2007 CLC bioGustav Wieds Vej 108000 Aarhus CDenmarkTelephone: +45 70 22 55 09 Fax: +45 70 22 55 ExplainedBioinformatics Explained : BLASTB ioinformatics Explained : BLASTBLAST (Basic Local Alignment Search Tool) has become thedefactostandard in search andalignment tools [Altschul et al., 1990]. The Blast algorithm is still actively being developedand is one of the most cited papers ever written in this field of biology. Many researchersuse Blast as an initial screening of their sequence data from the laboratory and to get anidea of what they are working on. Blast is far from being basic as the name indicates; itis a highly advanced algorithm which has become very popular due to availability, speed, andaccuracy. In short, a Blast search identifies homologous sequences by searching one ormore databases usually hosted by NCBI ( ), on the querysequence of interest [McGinnis and Madden, 2004].
Bioinformatics explained: BLAST After initial finding of words (seeding), the BLAST algorithm will extend the (only 3 residues long) alignment in both directions (see figure 3). Each time the alignment is extended, an alignment score is increases/decreased. When the alignment score drops below a predefined threshold, the extension of the ...
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