Transcription of BIOPHARMACEUTICS CLASSIFICATION SYSTEM
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BIOPHARMACEUTICS CLASSIFICATION SYSTEM
BIOPHARMACEUTICS CLASSIFICATION SYSTEMB asic Absorption and DispositionDrug at Absorption SiteDrug in BodyExcreted DrugMetabolitesabsorptionmetabolismexcre tionClinical Pharmacokinetics, Rowland and Tozer, 2nd Ed, Lea & Febiger, 1989 These models use curve-fitting techniques to estimate kinetic rate constants and other parameters from time-course data for blood, tissue, or excreta; however, the curve-fitted parameters lack biological , J., Pharmac Ther, 12:537-562, 19812 PharmacokineticsDISPOSITION OF DRUGSThe disposition of chemicals entering the body (from Klaassen, Casarett and Doull s Toxicology, 5th ed., New York: McGraw-Hill, 1996).Introduction BIOPHARMACEUTICS CLASSIFICATION SYSTEM (BCS) Scientific framework for classifying drug substances based on their aqueous solubility and intestinal permeability What is the need for a CLASSIFICATION based on BIOPHARMACEUTICS of the drug? Ans. Its importance in determining bioavailability Route of choice for the formulators Continues to dominate the area of drug delivery technologies.
Methods other than shake flask method (with Justification). e g. acid or base titration methods ... biopharmaceutical and physical properties of the drug ... rate and certain physicochemical properties of drugs like pH-solubility profile of drug. Class I - …
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