Transcription of Breakthrough in Nanoparticle Tracking Analysis (NTA)
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Breakthrough in Nanoparticle Tracking Analysis (NTA)
Breakthrough in Nanoparticle Tracking Analysis (NTA) April 2017 Rick Cooper, CEO Outline Background Technology overview Validation results Product details Established Technologies Dynamic Light Scattering (DLS) Nanoparticle Tracking Analysis (NTA) Transmission Electron Microscopy (TEM) Flow Cytometry (FC) Unmet Needs Visualization of polydisperse particles Accurate & reproducible measurement of: Particle number concentration Particle size distribution Particle kinetic processes Technology Light Scattering 101 In Brownian motion, particle movements are related to their size: & movements are measured by Tracking scattered light in videos LASER CCD Problem 100M X Scattered Light Intensity 450 nm laser on polystyrene beads Diameter [nm] Angular scattering coefficient [1/m] 10 100 1000 1E-19 1E-17 1E-15 1E-13 1E-21 1E-23 100M X Scattered Light Intensity Problem & Effects DLS large particles skew results NTA different sized particles co-existing can t be seen Problem is Well Known Sample polydispersity affects the ability to track and therefore a
Breakthrough in Nanoparticle Tracking Analysis (NTA) April 2017 Rick Cooper, CEO rick.cooper@mantainc.com 858.449.5801
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