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Bugs n drugs - Emory University

Bugs N drugs General Principles of Antimicrobial Therapy Hina N. Patel, , BCPS I. Basic Considerations a. Empiric treatment i. Site of infection ii. Likely pathogens iii. Hospital specific antibiogram b. Antibiotic spectrum of activity c. Penetration of antibiotic into body tissues d. Toxicity e. Allergies f. Cost II. Susceptibilities (MIC and MBC) a. MIC minimum inhibitory concentration (reported with culture) b. MBC minimum bactericidal concentration c. Relationship between drug concentration and MIC i. Must have concentrations at least 5-10 times the MIC to be susceptible ii. Susceptible, intermediate and resistant are based on peak concentration:MIC ratios iii.

Treatment of polymicrobial infection iii. Empiric therapy in immunocompromised patient iv. Synergism with certain combinations ... Rheumatic fever, prophylaxis, syphilis Procaine Penicillin (IM) Pharyngitis ... tissue infections and peritonitis Imipenem (IV – Primaxin)

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