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C. difficile Infection (CDI) Testing Algorithm: PCR/Reflex ...

C. difficile Infection (CDI) Testing Algorithm: PCR/Reflex Toxin EIA (5/14/2021) >3 observed watery stools within 24 hours Alternate explanation ( laxative, PO contrast)? DO NOT ORDER C. difficile PCR If diarrhea-causing medication present, stop medication and re-evaluate in 24-48 hours C. diff PCR previously sent within 7 days? Was prior test positive? DO NOT SEND C. difficile PCR FOR TEST-OF-CURE If diarrhea improving, continue current management. If diarrhea worsening: - Escalate therapy - Consider ID consult ORDER Stool C.

May 14, 2021 · C. difficile Toxin EIA POSITIVE Order Contact Plus isolation. Treat for C. difficile infection Stop unnecessary oral/IV antibiotics NEG PCR POS PCR Key Points: Identify new onset of unexplained large-volume, frequent, liquid diarrhea and consider a broad differential diagnosis. This process of medical decision-making is unchanged.

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