Transcription of Calcium Channel Blockers
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Calcium Channel Blockers
Calcium Channel BlockersDecember 1997iiCalcium Channel Blockers (CCBs) are used in thetreatment of many cardiovascular conditions. Althoughthey have generally been effective and well tolerated,recent concerns about their safety await the results ofwell designed, long term clinical trials PharmacologyThe Non-dihydropyridine CCBs such as verapamil(Isoptin ) and diltiazem (Cardizem ) cause lessvasodilation and more cardiac depression thandihydropyridine CCBs. They have negative effects at theSA and AV nodes, and cause reductions in heart rate andcontractility. Verapamil has the most pronouncednegative inotropic effect. Both are used in the treatmentof hypertension (HTN), angina, and supraventriculartachycardias and non-obstructive Dihydropyridine CCBs, nifedipine (Adalat ),felodipine (Renedil /Plendil ), amlodipine(Norvasc ), and nicardipine (Cardene ) have morevascular selectivity and fewer cardiac effects.
The Rx Files - December 1997 Calcium Channel Blockers References: 1 Furberg CD, Psaty BM, Meyer JV. Nifedipine - dose-related increase in mortality in patients with coronary heart disease. Circulation
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