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CALQUENCE PRESCRIBING INFORMATION

US-33441 HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include all the INFORMATION needed to use CALQUENCE safely and effectively. See full PRESCRIBING INFORMATION for (acalabrutinib) capsules, for oral use Initial Approval: 2017-------------------------------- RECENT MAJOR CHANGES ---------------------------------Indicat ions and Usage ( ) 11/2019 Dosage and Administration ( ) 11/2019--------------------------------- INDICATIONS AND USAGE ---------------------------------CALQUEN CE is a kinase inhibitor indicated for the treatment of adult patients with: Mantle cell lymphoma (MCL) who have received at least one prior therapy.

Refer to the obinutuzumab prescribing information for management of obinutuzumab toxicities. 3 DOSAGE FORMS AND STRENGTHS 100 mg capsules. 4 CONTRAINDICATIONS None. 5 WARNINGS AND PRECAUTIONS 5.1 Serious and Opportunistic Infections Fatal and serious infections, including opportunistic infections, have occurred in

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