Transcription of Cardiovascular Pathophysiology : Left To Right …
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Cardiovascular Pathophysiology : Left To Right …
1 CardiovascularPathophysiology: left To Right ShuntsIsmee A. Williams, MD, Objectives Learn the relationships betweenpressure, blood flow, and resistance Review the transition from fetal tomature circulation Correlate clinical signs and symptomswith cardiac physiology as it relates toleft to Right shunt lesions: VSD, PDA, ASD Discuss Eisenmenger s Syndrome2 Pressure, Flow, Resistance Perfusion Pressure: Pressuregradient across vascular bed ! Mean Arterial - Venous pressure Flow: Volume of blood that travelsacross vascular bed Resistance: Opposition to flow Vessel diameter Vessel structure and organization Physical characteristics of bloodPoiseuille equationQ = !P"r4 R =8nl 8nl"r4!P = pressure dropr = radiusR = !Pn = viscosity Ql = length of tubeQ = flow3 Hemodynamics! PressureFlow (Q) =Resistance! PressureResistance = FlowTwo parallel fetal circulations!Placenta suppliesoxygenated blood viaductus venosus!
1 Cardiovascular Pathophysiology : Left To Right Shunts Ismee A. Williams, MD, MS iib6@columbia.edu Learning Objectives ¥Learn the relationships between pressure, blood flow, and resistance
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