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造血干细胞发育的分子机制 - CAS

: 2016 46 1 : 16 ~ 24 SCIENTIA SINICA Vitae : , , .. : , 2016, 46: 16 24 Wang L, Zhang C X, Liu F. Molecular regulation of hematopoietic stem cell development. Sci Sin Vitae, 2016, 46: 16 24, doi: 2016 SCIENCE CHINA PRESS , , * , , 100101 * , E-mail: : 2015-07-23; : 2015-08-20 ( : 31271570, 31425016) , . , . ( ) , , . , , , , (hematopoietic stem cells, HSCs) , , [1].

最近的研究表明, Hedgehog-Notch是生血内 皮的产生所必需的信号, 其后, 通过Scl 的诱导作用 产生造血干细胞[33]. 除此之外, Hedgehog 信号通路还 通过Crlra(calcitonin receptor-like receptor)调控Notch 信号通路, 进而调控动脉产生, 这一过程是VEGF 非 依赖性的[34].

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