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Celiac Disease Diagnostic Testing Algorithm

10/2018 Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. Celiac Disease Diagnostic Testing AlgorithmTesting for selective IgA deficiencyIGA / Immunoglobulin A (IgA), SerumTTGA / Tissue Transglutaminase (tTG) Antibody, IgA, SerumIgA 1 mg/dL and below age-matched reference values TSTGP / Tissue Transglutaminase (tTG)Antibodies, IgA and IgG Pro le, Serum DGLDN / Gliadin (Deamidated) AntibodiesEvaluation, IgG and IgA, Serum< U/mLCeliac Disease very : ~10% of patients with celiacdisease are seronegativeIf Celiac Disease is highlysuspected, consider CELI / Celiac Associated HLA-DQ Alpha 1 and DQ Beta 1 DNA Typing, Blood DAGL / Gliadin (Deamidated)Antibody, IgA, Serum EMA / Endomysial Antibodies(IgA), SerumProceed to biopsySelective IgA deficiency* TTGG / Tissue Transglutaminase(tTG) Antibody, IgG, Serum DGGL / Gliadin (Deamidated)Antibody, IgG, SerumAny result positive or equivocalAll results normalCeliac Disease

© Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. 10/2018 Celiac Disease Diagnostic Testing Algorithm Testing for selective IgA ...

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