Cell Reports Report - Cycloastragenol

Cell ReportsReportTelomere Length Correlateswith Life Span of Dog BreedsLaura J. Fick,1 Gordon H. Fick,2 Zichen Li,1 Eric Cao,1Bo Bao,1 Doug Heffelfinger,3 Heidi G. Parker,4 Elaine A. Ostrander,4and Karl Riabowol1,*1 Department of Biochemistry and Molecular Biology2 Department of Community Health Sciences, Faculty of MedicineUniversity of Calgary, Calgary, AB T2N 4N1, Canada3 Crestwood Veterinary Clinic, Edmonton, AB T5P 1J9, Canada4 National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, DNA repeats are lost as normal somaticcells replicate. When telomeres reach a criticallyshort length, a DNA damage signal is initiated,inducing cell senescence. Some studies have indi-cated that telomere length correlates with mortality,suggesting that telomere length contributes tohuman life span; however, other studies Report nocorrelation, and thus the issue remains dogs show parallels in telomere biology tohumans, with similar telomere length, telomere attri-tion, and absence of somatic cell tel

Cell Reports Report Telomere Length Correlates with Life Span of Dog Breeds LauraJ.Fick,1 GordonH.Fick,2 ZichenLi,1 EricCao,1 BoBao,1 DougHeffelfinger,3 HeidiG.Parker,4 ElaineA.Ostrander,4 and Karl Riabowol1,* 1Department of Biochemistry and Molecular Biology 2Department of Community Health Sciences, Faculty of Medicine University of Calgary, Calgary, AB T2N 4N1, Canada

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