Transcription of Chapter 10: CARCINOGENICITY DEFINITIONS
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Chapter 10: CARCINOGENICITY DEFINITIONS
Chapter 10: CARCINOGENICITY DEFINITIONS 1. The term "carcinogen" denotes a chemical substance or a mixture of chemical substances which induce cancer or increase its incidence. Substances which have induced benign and malignant tumours in well performed experimental studies on animals are considered also to be presumed or suspected human carcinogens unless there is strong evidence that the mechanism of tumour formation is not relevant for humans. 2. classification of a chemical as posing a carcinogenic hazard is based on the inherent properties of the substance and does not provide information on the level of the human cancer risk which the use of the chemical may represent. CONSIDERATIONS 3. The purpose of the harmonised system for the classification of chemicals which may cause cancer is to provide common ground which could be used internationally for the classification of carcinogenic substances.
Classification of a chemical as posing a carcinogenic hazard is based on the inherent properties of the substance and does not provide information on the level of the human cancer risk which the use of the chemical may represent.
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