Transcription of Chapter 11. The Drug Discovery Process - Elsevier
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Chapter 11. The Drug Discovery Process - Elsevier
Chapter 11 The drug Discovery ProcessSuccess is the ability to go from failure to failure with no lack of Winston Churchill (1874 1965)I am interested in physical medicine because my father was. I am interested in medical research becauseI believe in it. I am interested in arthritis because I have Bernard Baruch, techniques may be generating bigger haystacks as opposed to more Horrobin, Some Challenges for Modern Target-Based drug Systems-Based drug vivoSystems, Biomarkers, andClinical Types of Therapeutically ActiveLigands: Pharmacology in drug Chemical Sources for Pharmacodynamics and High-Throughput drug Clinical Summary and SOME CHALLENGES FOR MODERNDRUG DISCOVERYThe identification of primary biological activity at the tar-get of interest is just one of a series of requirements for adrug. The capability to screen massive numbers of com-pounds has increased dramatically over the past 10 15years, yet no corresponding increase in successfullylaunched drugs has ensued.
Figure 11.1, the number of new drug entities over the years has decreased. This particular representation is nor-malized against the increasing costs of drug discovery and development, but it does reflect some debilitating trends in the drug discovery process. Undue reliance on robotic screening using simplistic single gene target
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