Transcription of Chapter 14. Enzyme Kinetics
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Chapter 14. Enzyme Kinetics
Chapter 14. Enzyme Kinetics Chemical Kinetics Elementary reactions A P (Overall stoichiometry). I1 I2 (Intermediates). Rate equations aA + bB + +zZ P. Rate = k[A]a[B]b [Z]z k: rate constant The order of the reaction (a+b+ +z): Molecularity of the reaction Unimolecular (first order) reactions: A P. Bimolecular (second order) reactions: 2A P or A + B P. Termolecular (third order) reactions Rates of reactions A P (First-order reaction). d[P] d[A]. v= =- = k[A]. dt dt 2A P (Second-order reaction). d[P] d[A]. v= =- = k[A]2. dt dt A + B P (Second-order reaction). d[P] d[A] d[B]. v= =- =- = k[A][B]. dt dt dt Rate constant for the first-order reaction d [A].
Modes of the reversible inhibition • Competitive inhibitors – Binds to the substrate binding site • Uncompetitive inhibitors – Binds to enzyme-substrate complex • Non-competitive inhibitors – Binds to a site different from the substrate binding site • Mixed inhibitors – Binds to the substrate-binding site and the enzyme-substrate
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