Transcription of Chapter 17: Adaptive (specific) Immunity - Sacramento State
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Chapter 17: Adaptive (specific) Immunity - Sacramento State
Adaptive Immunity Host defenses that are specific to a Chapter 17: particular infectious agent Can be innate or genetic for humans as a Adaptive ( specific ) Immunity group: most microbes can only infect certain species Most specific immune responses improve Bio 139 with repeated exposures to the infectious Dr. Amy Rogers agent or antigen Adaptive Immunity : 2 kinds Humoral Immunity Humoral & Cell-mediated B cells Humoral Immunity : mediated by are lymphocytes (leukocytes of the antibodies circulating in the blood. lymphoid lineage). B cells are produced & differentiate in (human). bone marrow Cell-mediated Immunity : Subsequently, they circulate/reside in blood &. T cells various lymphoid tissues produce antibodies Antibodies Antigens Are substances that trigger an immune are proteins response, including (but not only) antibody have highly specific binding sites for production by B cells antigen The best antigens (that provoke the Each individual antibody is specific for ONE.)
Ig structure: •Y-shaped •Variable region with two antigen binding sites at tips of Y •Constant region “stem” Immunoglobulin classes: IgG • Ig classes differ in structure of constant region • Each Ig class has a different function • All Ig’s bind specific antigens IgG: •Prominent in blood •Main antibody of memory (secondary ...
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