Transcription of Chapter 20: Antimicrobial Drugs
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Chapter 20: Antimicrobial Drugs
Chapter 20: Antimicrobial Drugs2. Antibacterial Drugs1. Overview of Antimicrobial Drugs3. Antiviral Drugs4. Drugs for Eukaryotic Pathogens1. Overview of Antimicrobial DrugsAntibioticsAn antibioticis technically a substance produced a microorganism to inhibit or killother microorganisms: , the mold Penicillium chrysogenumproducespenicillinwhich kills Gram+bacteriaIn practice, though, the term antibioticis used to refer to anysubstance, natural or synthetic, that inhibits or kills microorganisms: when used therapeutically, antibiotics are Antimicrobial Drugs !Antibiotics should not harm the HostFor an antibioticto be an effective drug , it must cause significantly greater harm to the pathogen than to the host being treated: this requires the targeting of features of thepathogen that differ from the host s cells bacteria have several such targets such as thecell wall & ribosomes viruses and eukaryotic pathogens are muchmore challenging to treat since they have lessfeatures that can be safelytargetedEfficacy vs Toxicity the higher the chemotherapeutic index,the safer the of Antimicrobial DrugsThe range of pathogens targeted by a specificantibiotic is referred to as its spectrum.
Chapter 20: Antimicrobial Drugs 2. Antibacterial Drugs 1. Overview of Antimicrobial Drugs 3. Antiviral Drugs 4. Drugs for Eukaryotic Pathogens
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