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Chapter 28a: Shingles (herpes zoster) 28a - GOV.UK

1 Shingles (herpes zoster) Chapter 28a: Shingles (herpes zoster) 23 August 2021 Shingles (herpes zoster) The diseaseShingles (herpes zoster) is caused by the reactivation of a latent varicella zoster virus (VZV) infection, generally decades after the primary infection. Primary VZV infection typically occurs during childhood and causes chickenpox (varicella); further information on this can be found in Chapter 34. Following primary VZV infection, the virus enters the sensory nerves and travels along the nerve to the sensory dorsal root ganglia and establishes a permanent latent infection.

also immunogenic in individuals who have had a history of shingles prior to vaccination (Levin et al., 2008). In the first three years of the UK vaccine programme with Zostavax®, vaccine effectiveness was 64% (95% CI 60-68%) against incident zoster and 81% (95% CI 61-91%) against PHN, with very similar VE estimates in the routine and catch-up

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Transcription of Chapter 28a: Shingles (herpes zoster) 28a - GOV.UK

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