Transcription of Chapter 3
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Chapter 3
Chapter 3 Protein Structure and FunctionBroad functional classesSo Proteins have structure and Fine!-Why do we care to know more????Understanding functional architechture gives usPOWERto: Diagnose and find reasons for diseases Create modifying drugs Engineer our own designer-proteinsDNA(mRNA)Translation:Tr anslation into 3D structure:3D structure determines function:Modifications:Chemical modification of aminoacidsInteraction with other moleculesProteolytic cleavage(Location)New 3D structureNew functionaProteins are single, unbranched chains of amino acid monomersaThere are 20 different amino acidsaThe amino acid sidechains in a peptide can become modified, extending the functional repetoire of aminoacids to more than hundred different amino protein s amino acid sequence determines its three-dimensional structure (conformation) aIn turn, a protein s structure determines the function of that proteinaConformation (=function) is dynamically regulated in several different waysProtein structure determines functionAll amino acids have the same general
Four levels of structure determine the shape of proteins aPrimary: the linear sequence of amino acids peptide bonds aSecondary: the localized organization of parts of a polypeptide chain (e.g., the αhelix or βsheet)
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