Transcription of Chapter 3
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Chapter 3 Protein Structure and FunctionBroad functional classesSo Proteins have structure and Fine!-Why do we care to know more????Understanding functional architechture gives usPOWERto: Diagnose and find reasons for diseases Create modifying drugs Engineer our own designer-proteinsDNA(mRNA)Translation:Tr anslation into 3D structure:3D structure determines function:Modifications:Chemical modification of aminoacidsInteraction with other moleculesProteolytic cleavage(Location)New 3D structureNew functionaProteins are single, unbranched chains of amino acid monomersaThere are 20 different amino acidsaThe amino acid sidechains in a peptide can become modified, extending the functional repetoire of aminoacids to more than hundred different amino protein s amino acid sequence determines its three-dimensional structure (conformation) aIn turn, a protein s structure determines the function of that proteinaConformation (=function) is dynamically regulated in several different waysProtein structure determines functionAll amino acids have the same general struct
Folding, modification, and degradation of proteins The life of a protein can briefly be described as: synthesis, folding, modification, function, degradation.
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Biology, Techniques, In molecular, Molecular biology, 4 Victorian Certificate of Education BIOLOGY, Molecular, International Baccalaureate, Techniques in Molecular Biology to, Statement of Purpose, Royal Society of Chemistry, Luria Broth (LB) and Luria Agar (LA) Media and Their, Guide to Baculovirus Expression Vector Systems BEVS