Transcription of Chapter 4 The Dose-Response Relationship
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Chapter 4 The Dose-Response Relationship
Chapter 4 The Dose-Response Relationship Introduction The need to establish some criteria to base the relative safety of chemicals is essential. Several methods are used to obtain data in order to establish safe levels and provide information about the relative toxicity of chemicals. Acute Toxicological Studies (1) Information concerning the toxicity of a substance is obtained primarily from either acute or chronic toxicity studies. Acute toxicity studies are the most commonly performed studies for obtaining information on the effects of chemical exposure.
Dose-Response Curves (2) • The threshold is the dose below which no effect is detected or above which an effect is first observed. • The threshold information is useful information in extrapolating animal data to humans and calculating what may be considered a safe human dose for a given toxic substance. • The threshold dose (ThD 0.0
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