Transcription of Chapter 4 The Dose-Response Relationship
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Chapter 4 The Dose-Response Relationship
Chapter 4 The Dose-Response Relationship Introduction The need to establish some criteria to base the relative safety of chemicals is essential. Several methods are used to obtain data in order to establish safe levels and provide information about the relative toxicity of chemicals. Acute Toxicological Studies (1) Information concerning the toxicity of a substance is obtained primarily from either acute or chronic toxicity studies. Acute toxicity studies are the most commonly performed studies for obtaining information on the effects of chemical exposure. They are short-term, relatively inexpensive tests with death of the test animal being the useful observed effect.
experimental data to produce a dose-response curve of best fit. 2. By statistical calculation an upper 95% confidence limit of the curve is determined 3. The Benchmark Response is defined as 10% (or 5%, or 1%). 4. The Benchmark Dose corresponds to the bench mark response on the upper confidence limit curve.
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