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Animal use intoxicity studiesChapter 9155 The ethics of research involving animalsCHAPTER 9 ANIMAL USE IN toxicity STUDIESA nimal use in toxicity In this Chapter we describe the purpose and principal methods of toxicity studies. Most ofthese studies are conducted to assess the degree to which substances are toxic (poisonous)for humans, animals or the environment, to investigate the mechanism of toxic chemicals, orto develop new or improved tests for specific types of chemically induced effects. We beginby explaining the scientific rationale behind important types of studies. These include:examination of adverse effects that may occur on first exposure to a single dose of asubstance (acute toxicity studies), studies that seek to assess the potential of substances tointeract with genetic material (genotoxicity), tests that aim to identify whether toxicityoccurs after continuous exposure to a substance (r)
155 The ethics of research involving animals CHAPTER 9 ANIMAL USE IN TOXICITY STUDIES Animal use in toxicity studies Introduction 9.1 In this chapter we describe the purpose and principal methods of toxicity …
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