Transcription of Chapter 6 Linkage Analysis and Mapping Three …
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Chapter 6 Linkage Analysis and Mapping Three …
Linkage Analysis and MappingChapter 6 Three point crosses Mapping strategy examples! Mapping human genesThree point crosses Faster and more accurate way to map genes Simultaneous Analysis of Three markers Information on the position of Three genes relative to each other canbe obtained from one mating rather than two independent matings. Example: Drosophila autosomal genes: vg = vestigial wings; vg+ = normal b = black body; b+ = normal body pr = purple eyes; pr+ = normal eyes Cross of pure breeding vestigial winged, black bodied, purple eyedfemale to a pure breeding wild type male: vgvg bb prpr x vg+vg+ b+b+ pr+pr+2/39 Three Factor Testcrosses Result in EightPhenotypic Progeny Classes3/39 Types of Gametes Parental Types Single Crossoverbetween A & B/a & b Single Crossoverbetween B & C/b & C Double CrossoverData Analysis There are eight gametes from the F1 largest number is parental smallest number is double crossover Identify the parental and recombinants Two genes at
Linkage Analysis and Mapping Chapter 6 Three point crosses ¥mapping ¥strategy ¥examples!Mapping human genes
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