Transcription of Chapter 7: Diptheria; Epidemiology and Prevention of ...
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Chapter 7: Diptheria; Epidemiology and Prevention of ...
diphtheria diphtheria is an acute, toxin-mediated disease caused by the bacterium Corynebacterium diphtheriae. The name of the disease is derived from the Greek diphthera, meaning leather hide. The disease was described in the 5th century BCE by Hippocrates, and epidemics were described in the 6th century AD by Aetius. The bacterium was first observed in diphtheritic membranes by Klebs in 1883 and cultivated by L ffler in 1884. Antitoxin was invented in the late 19th century, and toxoid was developed in the 1920s. Corynebacterium diphtheriae C. diphtheriae is an aerobic gram-positive bacillus. Toxin 7. production (toxigenicity) occurs only when the bacillus is diphtheria itself infected (lysogenized) by a specific virus (bacterio- Greek diphthera phage) carrying the genetic information for the toxin (tox (leather hide).)
Diphtheria. 101. 7. been given. Elimination of the organism should be documented by two consecutive negative cultures taken 24 hours apart, with the first specimen collected 24 …
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