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Chronic Obstructive Pulmonary Disease (COPD)

Chronic Obstructive Pulmonary Disease ( copd ) copd :OutlineCOPD: Outline DefinitionDefinition Etiology Epidemiology Epidemiology PathophysiologyCli i lPtti Clinical Presentation Diagnosis Prevention TreatmentCOPD:DefinitionCOPD: DefinitionChronic airflow obstruction due to Chronic bronchitis and/or Pulmonary emphysemaCOPD:DefinitionCOPD: DefinitionChronicairflow obstruction due to Chronic bronchitis and/or Pulmonary emphysemaCOPDis a chronicdiseaseCOPD is a Chronic Disease NotacuteairflowobstructionNotacute airflow obstruction Bronchitis/bronchiolitisAsthmaattack Asthma attack Not(completely)reversible Not(completely) reversible Asthma reversibleairflow obstructionCOPD:DefinitionCOPD: DefinitionChronic airflow obstruction due to Chronic bronchitis and/or Pulmonary emphysemaAirflowObstructionAirflow Obstruction Definitionof airflowobstructionDefinition of airflow obstruction FEV1/FVC < aka Obstructive ventilatory defect Alternative definition FEV1/FVC < lower limit of normal copd :DefinitionCOPD: DefinitionChronic airflow obstruction due to ch

AAT genotypes and emphysema riskAAT genotypes and emphysema risk Genotype Prevalence A1AT Serum Risk of Concentration Emphysema MM 91% 150-350 mg/dL Background MS 6% 110-340 mg/dL Background MZ 3% 90-210 /210 mg/dL Bk dBackground SS 0.1% 100-200 mg/dL Background SZ 0.1% 75-120 mg/dL 20-50% ZZ 0.02% 20-45 mg/dL 80-100% Stoller JK and Aboussouan LS.

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  Disease, Chronic, Chronic obstructive pulmonary disease, Obstructive, Pulmonary, Copd, Emphysema

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