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CLIA-Compliant Analytical Method Validation Plan and ...

LRN-C Analytical Method Validation PLAN & TEMPLATE 20131 TABLE OF CONTENTS List of LRN Clients and Requirements for Analytical Method Performance Method Performance Specifications and Validation Analytical Method Validation Plan and TemplateFOR LRN-C LABORATORIESISSUES IN BRIEF: LRN-C Analytical Method Validation PLAN & TEMPLATE DECEMBER 2013 LIST OF ACRONYMSEQA External Quality AssessmentHPLC-MS/MS High-Performance Liquid Chromatography Tandem mass SpectrometryIS Internal StandardLDT Laboratory Developed Test(s)LOD Limit of DetectionLOQ Limit of QuantitationPK/PD Pharmacokinetic/Pharmacodynamic modelingTEa Total Allowable ErrorULOL Upper Limit of Linearity APHL PUBLIC HEALTH LABORATORIES2 INTRODUCTION The Laboratory Response Networki (LRN) and its partners maintain an integrated national and international network of laboratories that can respond quickly to acts of chemical, radiological or biological terrorism, emerging infectious diseases and other public health threats and The Laboratory Response Network for Chemical Threatsii (LRN-C)

HPLC-MS/MS High-Performance Liquid Chromatography Tandem Mass Spectrometry IS Internal Standard LDT Laboratory Developed Test(s) ... A quality management system must be in place to ensure the delivery of timely and reliable services. The recommendations put forth in this document address only the establishment of ... For LC and GC methods, mass ...

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  Mass, Reliable, Spectrometry, Mass spectrometry

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