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Colonization Versus Infection - API

Colonization Versus Infection CHAPTER. R. Soman 42. Introduction wounds like osteomyelitis with/without a draining There are many clinical situations when Infection sinus and diabetic foot ulcers, cultures from post- is suspected but tests do not reveal the causative operative drains, positive urine cultures in an organism. On the other hand sometimes an organism asymptomatic patient and in a catheterized patient, is isolated but it is difficult to decide whether it is a sputum/respiratory specimen showing organisms in contaminant, colonizer or a true pathogen. a patient with suspected pneumonia, blood cultures in a patient with indwelling central venous catheter, We live in a sea of microbes and so it is not arterial line, hemodialysis catheter. surprising that microbes would contaminate clinical specimens and colonize almost all body surfaces. The points which help distinguish Colonization Hence surface specimens as well as those obtained Versus invasion are related to the findings at the site, the characteristics of the patient, the organism by penetrating skin or a mucous membranes need and on follow up.

Colonization Versus Infection 331 the other hand, an organism isolated from a non sterile specimen like sputum or a wound swab may be a colonizer. However it …

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