Transcription of COMMITTEE FOR VETERINARY MEDICINAL …
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COMMITTEE FOR VETERINARY MEDICINAL …
The European Agency for the Evaluation of MEDICINAL Products7 Westferry Circus, Canary Wharf, London E14 4HB, UKTel: (+44-171) 418 84 00 Fax: (+44-171) 418 84 16 EMEA 1999 Reproduction and/or distribution of this document is authorised for non commercial purposes only provided the EMEA is acknowledgedEMEA/MRL/042/95-FINALCOMMITT EE FOR VETERINARY MEDICINAL PRODUCTSCARPROFENSUMMARY REPORT (1)1. Carprofen, (6-chloro-alpha-methyl-9H-carbazole-2-ac etic acid) is a non-steroidal anti-inflammatorydrug. It is a racemic mixture with the D-isomer being more pharmacologically active than the L-isomer. In VETERINARY medicine it is used in horses and cattle. In cattle the proposed dosage is as a single intravenous or subcutaneous injection. In horses the proposed dosage is bw/day as an intravenous injection or by oral administration for up to 10 The general pharmacological profile of carprofen has been studied in experimental possesses strong anti-inflammatory and analgesic activities.
3/4 EMEA 1999 Residue depletion studies were conducted in horses using radiolabelled compound at a dose level of 0.7 mg/kg bw. At 7 days post intravenous administration, radioactive residues were detectable in
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