COMMON MORPHOLOGICAL ABNORMALITIES OF …

7 Learning Guide: WBC: Neutrophil GranulocytesFigure 6. Neutrophil granulocyte with hypersegmented 5. Pelger-Hu t cells with defective nuclear segmentation. A: Lack of nuclear lobes B: Bi-lobed nucleusFigure 5 AFigure 5 BCOMMON MORPHOLOGICAL ABNORMALITIES OF NEUTROPHIL GRANULOCYTESSome of the more COMMON ABNORMALITIES of neutrophil morphology that can be seen in peripheral blood are described ,12 1. PELGER HU T ANOMALYP elger Hu t anomaly is a rare benign autosomal dominant disorder characterized by defective nuclear segmentation (hypo-segmentation of the nucleus in neutrophils (Figure 5). Nuclei are bi-lobed, dumbbell-shaped or do not have lobes at all. It is important to differentiate from the acquired hypo-segmentation of the neutrophil nucleus, also called pseudo-Pelger Hu t anomaly, which has been observed in sepsis, myelodysplastic syndromes, hematological malignancies and in patients on certain transplant medications or other drugs.)

myelogenous leukemia. 3. DÖHLE BODIES Döhle bodies are single or multiple blue or grayish-blue cytoplasmic inclusions, representing free ribosomes or rough endoplasmic reticulum, usually situated at the periphery and protruding beyond the normal contour of the cell (Figure 7). They may be associated with myeloid left shifts, normal

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  Leukemia, Myelogenous, Myelogenous leukemia

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