COMMON MORPHOLOGICAL ABNORMALITIES OF …

7 Learning Guide: WBC: neutrophil GranulocytesFigure 6. neutrophil granulocyte with hypersegmented 5. Pelger-Hu t cells with defective nuclear segmentation. A: Lack of nuclear lobes B: Bi-lobed nucleusFigure 5 AFigure 5 BCOMMON MORPHOLOGICAL ABNORMALITIES OF neutrophil GRANULOCYTESSome of the more COMMON ABNORMALITIES of neutrophil morphology that can be seen in peripheral blood are described ,12 1. PELGER HU T ANOMALYP elger Hu t anomaly is a rare benign autosomal dominant disorder characterized by defective nuclear segmentation (hypo-segmentation of the nucleus in neutrophils (Figure 5). Nuclei are bi-lobed, dumbbell-shaped or do not have lobes at all. It is important to differentiate from the acquired hypo-segmentation of the neutrophil nucleus, also called pseudo-Pelger Hu t anomaly, which has been observed in sepsis, myelodysplastic syndromes, hematological malignancies and in patients on certain transplant medications or other drugs.)

The presence of dysplastic neutrophils is a characteristic feature ... Figure 10 demonstrates an example of a peripheral smear from a patient with myelodysplastic syndrome, showing ... neutrophils on peripheral blood smears.15 Counting …

Loading..

Tags:

  Blood, Peripheral, Smear, Dysplastic, Neutrophil, Dysplastic neutrophils, Peripheral smear, Neutrophils on peripheral blood

Information