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COMMON TOXICITY CRITERIA (CTC)

CTC Version Date: April 30, 1999 Cancer Therapy Evaluation Program1 Revised March 23, 1998 COMMON TOXICITY CRITERIA , Version , NCI, NIH, DHHS March 1998 COMMON TOXICITY CRITERIA (CTC)GradeAdverse Event01234 ALLERGY/IMMUNOLOGYA llergic reaction/hypersensitivity(including drug fever)nonetransient rash, drugfever <38 C (< F)urticaria, drug fever 38 C ( F),and/or asymptomaticbronchospasmsymptomaticbronc hospasm,requiring parenteralmedication(s), with orwithout urticaria;allergy-relatededema/angioedem aanaphylaxisNote: Isolated urticaria, in the absence of other manifestations of an allergic or hypersensitivity reaction, is graded in the DERMATOLOGY/SKIN rhinitis(including sneezing, nasalstuffiness, postnasal drip)nonemild, not requiringtreatmentmoderate, requiringtreatment--Autoimmune reactionnoneserologic or otherevidence ofautoimmune reactionbut patient isasymptomatic ( ,vitiligo), all organfunction is normal andno treatment is requiredevidence ofautoimmune reactioninvolving a non-essential organ orfunction ( ,hypothyroidism),requiring treatmentother thanimmunosuppressivedrugsreversible autoimmunereaction involvingfunction of a majororgan or other adv

Supraventricular arrhythmias (SVT/atrial fibrillation/ flutter) none asymptomatic, not requiring treatment symptomatic, but not requiring treatment symptomatic and requiring treatment life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock) Syncope (fainting) is graded in the NEUROLOGY category.

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  Toxicity, Arrhythmia

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