Transcription of COMMON TOXICITY CRITERIA (CTC)
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COMMON TOXICITY CRITERIA (CTC)
CTC Version Date: April 30, 1999 Cancer Therapy Evaluation Program1 Revised March 23, 1998 COMMON TOXICITY CRITERIA , Version , NCI, NIH, DHHS March 1998 COMMON TOXICITY CRITERIA (CTC)GradeAdverse Event01234 ALLERGY/IMMUNOLOGYA llergic reaction/hypersensitivity(including drug fever)nonetransient rash, drugfever <38 C (< F)urticaria, drug fever 38 C ( F),and/or asymptomaticbronchospasmsymptomaticbronc hospasm,requiring parenteralmedication(s), with orwithout urticaria;allergy-relatededema/angioedem aanaphylaxisNote: Isolated urticaria, in the absence of other manifestations of an allergic or hypersensitivity reaction, is graded in the DERMATOLOGY/SKIN rhinitis(including sneezing, nasalstuffiness, postnasal drip)nonemild, not requiringtreatmentmoderate, requiringtreatment--Autoimmune reactionnoneserologic or otherevidence ofautoimmune reactionbut patient i
Hemolysis (e.g., immune hemolytic anemia, drug-related hemolysis, other) none only laboratory evidence of hemolysis [e.g., direct antiglobulin test (DAT, Coombs’) schistocytes] evidence of red cell destruction and ≥2gm decrease in hemoglobin, no transfusion requiring transfusion and/or medical intervention (e.g., steroids) catastrophic ...
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