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COMPARISON OF ARTICAINE AND LIDOCAINE …

1 COMPARISON OF ARTICAINE AND LIDOCAINE USED AS DENTAL local ANESTHETICS by rjan Johansen Project Thesis 10. semester ( H-99) May 2004 Section of Dental Pharmacology and Pharmacotherapy, Institute of Clinical Dentistry, Faculty of Dentistry University of Oslo 2 Page Contents 2 Preface 3 Introduction 3 The basic properties of ARTICAINE and LIDOCAINE 4 Factors affecting local anesthetic action 5 Pharmacokinetics 6 Uptake 6 Distribution 7 Metabolism (Biotransformation) 7 Excretion 8 Pharmacodynamics 8 Clinical COMPARISON of ARTICAINE versus LIDOCAINE 9 Safety 9 Efficacy 10 Use in pediatric dentistry 13 Use in geriatric patients 15 Complications 16 Why is ARTICAINE delivered as a 4 % solution?

2 Page Contents 2 Preface 3 Introduction 3 The basic properties of articaine and lidocaine 4 Factors affecting local anesthetic action 5

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