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Considerations for Automating the Dissolution Test

Considerations for Automating the Dissolution Test G. Bryan Crist e-mail: Agilent Technologies, Cary, NC. A. primary challenge for the pharmaceutical labora- qualification, and in some cases can be such an obstacle tory is to maximize throughput with optimum that the automated system implementation is delayed compliance. A technique-dependent test like or never reaches the intended level of utilization. This Dissolution is a primary target for implementing vary- results in the versatility paradox of understanding that ing levels of automation, from semiautomated sampling what we want in a system may not be what we actu- equipment to fully robotic systems. Instrumentation ally need. The ability to have a system that completely flexibility will be required in the laboratory of the future automates sampling and the analytical finish is alluring, to minimize the potential for error caused by manual yet can unnecessarily increase complexity, cost, and in intervention and to fully utilize the Dissolution appara- the end, efficiency.

44 Dissolution Technologies | MAY 2013 Considerations for Automating the Dissolution Test G. Bryan Crist Agilent Technologies, Cary, NC A primary challenge for the pharmaceutical labora -

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