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Controlling Contamination in LC/MS

715001307 REV. G 1 OF 33. Controlling Contamination in LC/MS Systems Best Practices This document outlines best practices for Controlling Contamination in UPLC/MS and HPLC/. MS systems (both clinical and non clinical). A good Contamination control plan includes measures for preventing, troubleshooting, and cleaning Contamination . Important: This document updates, supersedes, and supplements all other Waters documents on preventing, troubleshooting, and cleaning Contamination . Note: To understand what causes Contamination , see Major contaminants and their sources, page 31.

Aggressive cleaning process If more aggressive cleaning is required (for example, when the container’s history is unknown), use the following procedure: 1. Sonicate with 10% formic or nitric acid, then water, then methanol or acetonitrile, then water. 2. Repeat two more times.

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  Acid, Cleaning, Contamination, Controlling, Controlling contamination in lc ms

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