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COVID-19 Clinical Working Group Summary Document Topic ...

COVID-19 Clinical Working Group Summary Document Topic : Comparative Immunogenicity Trials of Novel Candidate COVID-19 . Vaccines in a Seropositive Population Version: ; Dated 23 March 2022. Disclaimer: This Document provides a Summary of key points from the literature, guidelines or other documents from experts on the subject matter, including from national and multilateral organizations and authorities. This Document does not aim to be exhaustive. Due to the rapidly evolving situation, this Summary Document may not include latest evidence and updates are likely. New versions will be issued when significant new information becomes available.

may contribute more to the efficacy of adenoviral and mRNA than protein-based vaccines, including adjuvanted subunit and nanoparticle vaccines. The complex, composite nature of protection, as captured in the equation, is further illustrated by (i) the early onset of protection against symptomatic COVID-19 (i.e., 10 days after the first

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