Critical Care Intravenous Drug Administration Guide

CCrriittiiccaallCCaarreeIInnttrraavveenn oouussDDrruuggAAddmmiinniissttrraattiioo nnGGuuiiddee For Use on ICU, HDU & CTCCU Page 1 of 44 April 2008 (For review April 2009)DRUGMETHODADMINISTER OVERDILUTION & DILUENTY-SITE COMPATIBILITY & pHMONITORING, ADVERSE EFFECTS & COMMENTSA cetylcysteineInfusion for liver failure15mg/kg loading dose then over 24 hours for 5 dayspH: 7 adjusted with sodium not infuse with other drugs if possibleA change in colour to light purple does not indicate any change in safety or of NS as diluent is not in product licence but manufacturer has stability data. Infusion for paracetamol overdose150mg/kg loading dose over 15 minutes, then 50mg/kg over 4 hours, then 100mg/kg over 16 hoursCentral line:May be given undilutedPeripheral line: Minimum dilution each 10ml ampoule with 10mls of G or NSUsually dilute daily dose in 100mls NS or GFlush: G or NSSodium content: mmol/10mlInfusion for renal protection against contrast media3 mls (600mg) of 2g in 10ml injection100mls G or NS, infuse over to section 4 for more : 600mg BD day before and day of scanAciclovirIntermittent InfusionMinimum 1 hour with adequate hydration (aciclovir can precipitate in renal tubules if maximum solubility is exceeded)Reconstitute vial to 25mg/ml with W or NS if dry powder.

Sodium content: 1.6 mmol/500mg; 3.3mmol/1g Thrombophlebitis may occur at injection site. Intermittent infusion Over 30-60 minutes Reconstitue as above. Add to 50-100ml of G or NS FUNGIZONE Calculation Example for 17.5mg dose (250 micrograms /kg for 70kg patient) Reconstitute as below in 500mls buffered glucose 5% Flush line with glucose 5%

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  Administration, Guide, Critical, Drug, Care, Sodium, Intravenous, Glucose, Critical care intravenous drug administration guide

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