Transcription of Crohn Disease: Pathophysiology, Diagnosis, and Treatment
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Crohn Disease: Pathophysiology, Diagnosis, and Treatment
297 RADIOLOGIC TECHNOLOGY, January/February 2014, Volume 85, Number 3 CEDirected ReadingTo understand fully how Crohn disease develops and progresses, it is essential to recognize that the gastrointestinal (GI) tract of a healthy individual is in a state of dynamic immune homeostasis, or per-sistent naturally occurring inf lamma-tion. The immune system is responsible for balancing factors that activate its defense system and induce inf lammation while simultaneously down-regulating the inf lammation to maintain mucosal integrity. Because the mucosal surfaces that line the gut are the physical interfaces of the body s immune system with the outside world and the GI tract consists of a large portion of the body s mucosal lymphoid tissue, it is crucial that muco-sal integrity be maintained.
CE Directed Reading 298 RADIOLOGIC TECHNOLOGY, January/February 2014, Volume 85, Number 3 Crohn Disease: Pathophysiology, Diagnosis, and Treatment anus. Diarrhea and abdominal pain are common symp-toms, and the disease can be chronic, intermittent, or in
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