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cyclic-AMP (cAMP) cascade protein kinase A (PKA). PKA

Metabolism Lecture 7 METABOLIC_REGULATION Restricted for students enrolled in MCB102, UC Berkeley, Spring 2008 ONLY Bryan Krantz: University of California, Berkeley MCB 102, Spring 2008, Metabolism Lecture 7 Reading: Ch. 15 of Principles of Biochemistry, Principles of Metabolic Regulation, Illustrated with Glucose and Glycogen Metabolism. Epinephrine & the cAMP cascade . Epinephrine is secreted. There are many epinephrine receptors on the surface of muscle cells. Muscle is a characteristic organ where the effect of epinephrine takes place. The cyclic-AMP (cAMP) cascade begins with the production of cAMP, which is a pure signaling molecule, , not a metabolism intermediate.

This regulatory enzyme contains two distinct enzyme activities in two active sites on one single polypeptide chain. FPK-2 gets phosphorylated in the cAMP cascade in the liver. The effect of phosphorylation generally depends on the enzyme, but usually activity either goes up or down. When this giant

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Transcription of cyclic-AMP (cAMP) cascade protein kinase A (PKA). PKA

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cyclic-AMP (cAMP) cascade protein kinase A (PKA). …

mcb.berkeley.edu

The cyclic-AMP (cAMP) cascade begins with the production of cAMP, which is a pure signaling molecule, i.e., not a metabolism intermediate. cAMP binds and activates protein kinase A (PKA). PKA converts phosphorylase-b into phosphorylase-a, which is phosphorylated and active, in two steps. PKA converts glycogen

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