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Cytotoxic T lymphocytes and natural ... - Columbia University

Cytotoxic T lymphocytes and natural killer cellsMargrit WiesendangerDivision of General Medicine, CUMCS eptember 16, 2009 Killer cells: CD8+T cells (adaptive) vs. natural killer (innate)Shared purpose:protect the host from viral, bacterial and parasitic infectionrecognize and destroy malignant cellsShared mechanismsof cytotoxicity and similar cytokine secretion profilesDistinct modes of target recognitionCytotoxic T lymphocytes Express CD8 (potentiates interaction with class I MHC molecule) Each T cell expresses a unique receptor, within a highly diverse repertoire generated by V(D)J recombination Scan MHC class I-peptide complexes, searching for pathogen or tumor-encoded antigens Preactivation and differentiation requiredNatural killer cells Invariant activating and inhibitory receptors Recognize missing self.

Killer cells: CD8+ T cells (adaptive) vs. natural killer (innate) Shared purpose: protect the host from viral, bacterial and parasitic infection recognize and destroy malignant cells Shared mechanisms of cytotoxicity and similar cytokine secretion profiles Distinct modes …

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