David E. Huber1 Research Article Juan G. Santiago2 Taylor ...

David E. Huber1 juan G. Santiago21 Microfluidics Department,Sandia National Laboratories,Livermore, CA, USA2 Department of MechanicalEngineering,Stanford University,Stanford, CA, USAR eceived July 27, 2006 Revised December 19, 2006 Accepted January 5, 2007 Research ArticleTaylor Aris dispersion in temperaturegradient focusingMicrofluidic temperature gradient focusing (TGF) uses an axial temperature gradient toinduce a gradient in electrophoretic flux within a microchannel. When balanced with anopposing fluid flow, charged analytes simultaneously focus and separate according to theirelectrophoretic mobilities. We present a theoretical and experimental study of dispersion inTGF. We model the system using generalized dispersion analysis that yields a 1-D convec-tion-diffusion equation that contains dispersion terms particular to TGF.

Over the last decade, microfluidics technology has con-tributed to the development of many miniaturized bioanaly-tical techniques, in pursuit of the goal of the micro total analysis system (mTAS) or “lab-on-a-chip” system [1–3]. Miniaturization can yield significant performance improve-

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  Juan, David, Microfluidic, De vida, Huber1, Juan g, Santiago2

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